The Alteration of Brain Interstitial Fluid Drainage with Myelination Development.

Wang, Rui; Han, Hongbin; Shi, Kuangyu; Alberts, Ian Leigh; Rominger, Axel; Yang, Chenlong; Yan, Junhao; Cui, Dehua; Peng, Yun; He, Qingyuan; Gao, Yajuan; Lian, Jingge; Yang, Shuangfeng; Liu, Huipo; Yang, Jun; Wong, Chaolan; Wei, Xunbin; Yin, Feng; Jia, Yanxing; Tong, Huaiyu; ... (2021). The Alteration of Brain Interstitial Fluid Drainage with Myelination Development. Aging and disease, 12(7), pp. 1729-1740. Aging and Disease 10.14336/AD.2021.0305

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The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Shi, Kuangyu; Alberts, Ian Leigh and Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2152-5250

Publisher:

Aging and Disease

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

04 Jan 2022 14:11

Last Modified:

04 Jan 2022 14:11

Publisher DOI:

10.14336/AD.2021.0305

PubMed ID:

34631217

Uncontrolled Keywords:

brain development brain extracellular space interstitial fluid tracer-based MRI

BORIS DOI:

10.48350/161782

URI:

https://boris.unibe.ch/id/eprint/161782

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