Working memory task induced neural activation: A simultaneous PET/fMRI study.

Ripp, Isabelle; Wallenwein, Lara A; Wu, Qiong; Emch, Monica; Koch, Kathrin; Cumming, Paul; Yakushev, Igor (2021). Working memory task induced neural activation: A simultaneous PET/fMRI study. NeuroImage, 237, p. 118131. Elsevier 10.1016/j.neuroimage.2021.118131

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PURPOSE

Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) is a powerful method for mapping cerebral glucose metabolism as a proxy of neural activity, assuming a steady-state during the recording interval. We asked if a clinical FDG-PET imaging protocol might also capture changes in neural activity associated with performance of a working memory (WM) task.

METHODS

To test this concept, we examined hybrid PET/MR data for FDG-PET and simultaneous functional magnetic resonance imaging (fMRI) in a sample of healthy volunteers. The PET image acquisition started 30 min after a bolus injection of approximately 100 MBq FDG, and the WM task was undertaken starting at approximately 60 min post-injection. We reconstructed FDG-PET sum images corresponding to baseline (44-60 min p.i.) and WM tasks (63- 71 min p.i.), each with intensity scaling to the corresponding global mean.

RESULTS

Compared to the baseline resting condition, relative FDG uptake increased during WM task performance in brain regions previously associated with WM. Furthermore, these metabolically active regions partly overlapped with the regions showing task-dependent increases in BOLD signal in simultaneous fMRI.

CONCLUSION

We find evidence for WM task-induced neural activation using a clinical FDG-PET imaging protocol. These findings encourage the development of dedicated protocols for tracking neural correlates of cognitive function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Cumming, Paul

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1053-8119

Publisher:

Elsevier

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

07 Jan 2022 10:02

Last Modified:

09 Jan 2022 01:51

Publisher DOI:

10.1016/j.neuroimage.2021.118131

PubMed ID:

33951511

Uncontrolled Keywords:

Cognition FDG PET Neuroimaging Positron emission tomography fMRI

BORIS DOI:

10.48350/161803

URI:

https://boris.unibe.ch/id/eprint/161803

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