The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course

Mwinyi, Jessica; Grete-Wenger, Christa; Eloranta, Jyrki J.; Kullak-Ublick, Gerd A. (2012). The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research, 2012, p. 349469. New York, N.Y.: Hindawi Publishing Corporation 10.1155/2012/349469

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PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis. We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course. None of the detected 22 NR1C3 variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of the NR3C1 haplotypes showed association with IBD development or disease course. We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Juillerat, Pascal

ISSN:

1687-4757

Publisher:

Hindawi Publishing Corporation

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:40

Last Modified:

18 Dec 2014 19:27

Publisher DOI:

10.1155/2012/349469

PubMed ID:

22448164

Web of Science ID:

000301146200001

BORIS DOI:

10.7892/boris.16181

URI:

https://boris.unibe.ch/id/eprint/16181 (FactScience: 223769)

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