OMERACT definition and reliability assessment of chronic ultrasound lesions of the axillary artery in giant cell arteritis.

Schäfer, Valentin Sebastian; Chrysidis, Stavros; Schmidt, Wolfgang A; Duftner, Christina; Iagnocco, Annamaria; Bruyn, George A; Carrara, Greta; De Miguel, Eugenio; Diamantopoulos, Andreas P; Nielsen, Berit Dalsgaard; Fredberg, Ulrich; Hartung, Wolfgang; Hanova, Petra; Hansen, Ib Tønder; Hocevar, Alojzija; Juche, Aaron; Kermani, Tanaz A; Lorenzen, Tove; Macchioni, Pierluigi; Milchert, Marcin; ... (2021). OMERACT definition and reliability assessment of chronic ultrasound lesions of the axillary artery in giant cell arteritis. Seminars in arthritis and rheumatism, 51(4), pp. 951-956. Elsevier 10.1016/j.semarthrit.2021.04.014

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To define chronic ultrasound lesions of the axillary artery (AA) in long-standing giant cell arteritis (GCA) and to evaluate the reliability of the new ultrasound definition in a web-based exercise.


A structured Delphi, involving an expert panel of the Large Vessel Vasculitis subgroup of the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group was carried out. The reliability of the new definition was tested in a 2-round web-based exercise involving 23 experts and using 50 still images each from AA of long-standing and acute GCA patients, as well as 50 images from healthy individuals.


The final OMERACT ultrasound definition of chronic changes was based on measurement and appearance of the intima-media complex. The overall reliability of the new definition for chronic ultrasound changes in longstanding GCA of the AA was good to excellent with Light's kappa values of 0.79-0.80 for inter-reader reliability and mean Light's-kappa of 0.88 for intra-reader reliability. The mean inter-rater and intra-rater agreements were 86-87% and 92%, respectively. Good reliabilities were observed comparing the vessels with longstanding versus acute GCA with a mean agreement and kappa values of 81% and 0.63, respectively.


The new OMERACT ultrasound definition for chronic vasculitis of the AA in GCA revealed a good to excellent inter- and intra-reader reliability in a web-based exercise of experts.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Seitz, Luca Fabio


600 Technology > 610 Medicine & health








Brigitte Isenschmid

Date Deposited:

03 Dec 2021 10:16

Last Modified:

02 Mar 2023 23:35

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Axillary artery Chronic Definition Giant cell arteritis OMERACT Ultrasound




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