Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice

Natividad, Jane M M; Petit, Valerie; Huang, Xianxi; de Palma, Giada; Jury, Jennifer; Sanz, Yolanda; Philpott, Dana; Garcia Rodenas, Clara L; McCoy, Kathy D; Verdu, Elena F (2012). Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice. Inflammatory bowel diseases, 18(8), pp. 1434-46. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1002/ibd.22848

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The intestinal microbiota regulates key host functions. It is unknown whether modulation of the microbiota can affect a genetically determined host phenotype. Polymorphisms in the Nucleotide oligomerization domain (Nod)-like receptor family confer genetic risk for inflammatory bowel disease (IBD). We investigated whether the intestinal microbiota and the probiotic strain Bifidobacterium breve NCC2950 affect intestinal barrier function and responses to intestinal injury in Nod1(-/-); Nod2(-/-) mice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

McCoy, Kathleen

ISSN:

1078-0998

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:40

Last Modified:

17 Mar 2015 21:34

Publisher DOI:

10.1002/ibd.22848

PubMed ID:

22162005

Web of Science ID:

000306403300004

URI:

https://boris.unibe.ch/id/eprint/16183 (FactScience: 223771)

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