Evolution of COVID-19 mortality over time: results from the Swiss hospital surveillance system (CH-SUR).

Roelens, Maroussia; Martin, Alexis; Friker, Brian; Maximiano Sousa, Filipe; Thiabaud, Amaury; Vidondo, Beatriz Teresa; Buchter, Valentin; Gardiol, Céline; Vonlanthen, Jasmin; Balmelli, Carlo; Battegay, Manuel; Berger, Christoph; Buettcher, Michael; Cusini, Alexia; Flury, Domenica; Heininger, Ulrich; Niederer-Loher, Anita; Riedel, Thomas; Schreiber, Peter W; Sommerstein, Rami; ... (2021). Evolution of COVID-19 mortality over time: results from the Swiss hospital surveillance system (CH-SUR). Swiss medical weekly, 151, w30105. EMH Schweizerischer Ärzteverlag 10.4414/smw.2021.w30105

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BACKGROUND

When the periods of time during and after the first wave of the ongoing SARS-CoV-2/COVID-19 pandemic in Europe are compared, the associated COVID-19 mortality seems to have decreased substantially. Various factors could explain this trend, including changes in demographic characteristics of infected persons and the improvement of case management. To date, no study has been performed to investigate the evolution of COVID-19 in-hospital mortality in Switzerland, while also accounting for risk factors.

METHODS

We investigated the trends in COVID-19-related mortality (in-hospital and in-intermediate/intensive-care) over time in Switzerland, from February 2020 to June 2021, comparing in particular the first and the second wave. We used data from the COVID-19 Hospital-based Surveillance (CH-SUR) database. We performed survival analyses adjusting for well-known risk factors of COVID-19 mortality (age, sex and comorbidities) and accounting for competing risk.

RESULTS

Our analysis included 16,984 patients recorded in CH-SUR, with 2201 reported deaths due to COVID-19 (13.0%). We found that overall in-hospital mortality was lower during the second wave of COVID-19 than in the first wave (hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.63- 0.78; p <0.001), a decrease apparently not explained by changes in demographic characteristics of patients. In contrast, mortality in intermediate and intensive care significantly increased in the second wave compared with the first wave (HR 1.25, 95% CI 1.05-1.49; p = 0.029), with significant changes in the course of hospitalisation between the first and the second wave.

CONCLUSION

We found that, in Switzerland, COVID-19 mortality decreased among hospitalised persons, whereas it increased among patients admitted to intermediate or intensive care, when comparing the second wave to the first wave. We put our findings in perspective with changes over time in case management, treatment strategy, hospital burden and non-pharmaceutical interventions. Further analyses of the potential effect of virus variants and of vaccination on mortality would be crucial to have a complete overview of COVID-19 mortality trends throughout the different phases of the pandemic.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Friker, Brian; Maximiano Alves de Sousa, Filipe Miguel; Vidondo, Beatriz Teresa; Sommerstein, Rami and Marschall, Jonas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

09 Dec 2021 16:10

Last Modified:

12 Dec 2021 02:16

Publisher DOI:

10.4414/smw.2021.w30105

PubMed ID:

34843180

BORIS DOI:

10.48350/161868

URI:

https://boris.unibe.ch/id/eprint/161868

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