Papaefthymiou, Apostolis; Doulberis, Michael; Karafyllidou, Kyriaki; Chatzimichael, Eleftherios; Deretzi, Georgia; Exadaktylos, Aristomenis K.; Sampsonas, Fotios; Gelasakis, Athanasios; Papamichos, Spyros I.; Kotronis, Georgios; Gialamprinou, Dimitra; Vardaka, Elisabeth; Polyzos, Stergios A.; Kountouras, Jannis (2023). Effect of spironolactone on pharmacological treatment of nonalcoholic fatty liver disease. Minerva endocrinology, 48(3), pp. 346-359. Edizioni Minerva Medica 10.23736/S2724-6507.21.03564-8
Full text not available from this repository. (Request a copy)Nonalcoholic fatty liver disease (NAFLD) was recently renamed to metabolic (dysfunction)-associated fatty liver disease (MAFLD) to better characterize its pathogenic origin. NAFLD represents, at least in western societies, a potential epidemic with raising prevalence. Its multifactorial pathogenesis is partially unraveled and till now there is no approved pharmacotherapy for NAFLD. A plethora of various choices are investigated in clinical trials, targeting an arsenal of different pathways and molecules. Since the mineralocorticoid receptor (MR) and renin-angiotensin-aldosterone system (RAAS) appear to be implicated in NAFLD, within this concise review, we focus on a rather classical and inexpensive pharmacological agent, spironolactone. We present the current lines of evidence of MR and RAAS-related preclinical models and human trials reporting an association with NAFLD. In conclusion, evidence about spironolactone of RAAS is commented, as potential future pharmacological management of NAFLD.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Doulberis, Michael, Exadaktylos, Aristomenis |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2724-6116 |
Publisher: |
Edizioni Minerva Medica |
Language: |
English |
Submitter: |
Romana Saredi |
Date Deposited: |
08 Dec 2021 11:29 |
Last Modified: |
20 Sep 2023 00:10 |
Publisher DOI: |
10.23736/S2724-6507.21.03564-8 |
PubMed ID: |
34669319 |
URI: |
https://boris.unibe.ch/id/eprint/161911 |
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