Becchetti, Chiara; Ferrarese, Alberto; Zeni, Nicola; Russo, Francesco Paolo; Senzolo, Marco; Gambato, Martina; Bassi, Domenico; Cillo, Umberto; Burra, Patrizia; Germani, Giacomo (2022). A prospective longitudinal assessment of de novo metabolic syndrome after liver transplantation. Clinical transplantation, 36(2), e14532. Wiley-Blackwell 10.1111/ctr.14532
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BACKGROUND
De novo metabolic syndrome (MS) is a frequent complication after liver transplantation (LT). The aim of this prospective study is to identify potential risk factors longitudinally associated to post-LT de novo MS. Patients without pre-LT MS who underwent LT between April 2013 and October 2017 were prospectively included. Metabolic variables were collected at LT and at 6, 12, and 24 months post-LT.
RESULTS
Sixty-three patients fulfilled the inclusion criteria (76% male, mean age 53.6±9.5 years). The prevalence of de novo MS was 46%, 43%, and 49% at 6, 12, and 24 months after LT, respectively. Among other MS components, the prevalence of type 2 diabetes, hypertension and hypertriglyceridemia significantly increased after LT. Considering the baseline characteristics at the adjusted analysis, alcoholic liver disease (OR 4.17, 95%CI 1.20-14.51; p = .03) and hypertension pre-LT (OR 11.3, 95% CI 1.49-85.46; p = .02) were confirmed as independent risk factors of post-LT de novo MS. In the time-varying analysis, only eGFR (OR .97, 95% CI .97-.98; p < .0001) was found associated with post-LT de novo MS.
CONCLUSIONS
De novo MS frequently occurs shortly after LT, affecting nearly half of patients at 24 months post-LT. Lifestyle modifications should be recommended starting early post-LT, particularly for patients with established risk factors.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Becchetti, Chiara |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0902-0063 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
27 Dec 2021 11:35 |
Last Modified: |
05 Dec 2022 15:55 |
Publisher DOI: |
10.1111/ctr.14532 |
PubMed ID: |
34757678 |
Uncontrolled Keywords: |
arterial hypertension chronic kidney disease immunosuppressant kidney function metabolic complications new-onset diabetes after transplantation solid organ transplantation |
BORIS DOI: |
10.48350/161967 |
URI: |
https://boris.unibe.ch/id/eprint/161967 |
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