Meningitis, meningoencephalitis and encephalitis in Bern: an observational study of 258 patients.

Ungureanu, Anamaria; van der Meer, Julia; Bicvic, Antonela; Abbuehl, Lena; Chiffi, Gabriele; Jaques, Léonore; Suter-Riniker, Franziska; Leib, Stephen L.; Bassetti, Claudio L.A.; Dietmann, Anelia (2021). Meningitis, meningoencephalitis and encephalitis in Bern: an observational study of 258 patients. BMC neurology, 21(1), p. 474. BioMed Central 10.1186/s12883-021-02502-3

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BACKGROUND

Depending on geographic location, causes of encephalitis, meningoencephalitis and meningitis vary substantially. We aimed to identify the most frequent causes, clinical presentation and long-term outcome of encephalitis, meningoencephalitis and meningitis cases treated in the Inselspital University Hospital Bern, Switzerland.

METHODS

In this monocentric, observational study, we performed a retrospective review of clinical patient records for all patients treated within a 3-year period. Patients were contacted for a telephone follow-up interview and to fill out questionnaires, especially related to disturbances of sleep and wakefulness.

RESULTS

We included 258 patients with the following conditions: encephalitis (18%), nonbacterial meningoencephalitis (42%), nonbacterial meningitis (27%) and bacterial meningoencephalitis/meningitis (13%). Herpes simplex virus (HSV) was the most common cause of encephalitis (18%); tick-borne encephalitis virus (TBEV) was the most common cause of nonbacterial meningoencephalitis (46%), enterovirus was the most common cause of nonbacterial meningitis (21%) and Streptococcus pneumoniae was the most common cause of bacterial meningoencephalitis/meningitis (49%). Overall, 35% patients remained without a known cause. After a median time of 16 months, 162 patients participated in the follow-up interview; 56% reported suffering from neurological long-term sequelae such as fatigue and/or excessive daytime sleepiness (34%), cognitive impairment and memory deficits (22%), headache (14%) and epileptic seizures (11%).

CONCLUSIONS

In the Bern region, Switzerland, TBEV was the overall most frequently detected infectious cause, with a clinical manifestation of meningoencephalitis in the majority of cases. Long-term neurological sequelae, most importantly cognitive impairment, fatigue and headache, were frequently self-reported not only in encephalitis and meningoencephalitis survivors but also in viral meningitis survivors up to 40 months after acute infection.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Ungureanu, Anamaria; van der Meer, Julia; Bicvic, Antonela; Abbühl, Lena Simone; Chiffi, Gabriele; Jaques, Léonore Alexane; Suter, Franziska Marta; Leib, Stephen; Bassetti, Claudio L.A. and Dietmann, Anelia

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1471-2377

Publisher:

BioMed Central

Projects:

[UNSPECIFIED] Bangerter Rhyhner Stiftung
[UNSPECIFIED] CTU Research Grant of the University of Bern
[UNSPECIFIED] InterfacultInterfaculty Research Cooperation Grant “Decoding Sleep” by the University of Bern

Language:

English

Submitter:

Stephen Leib

Date Deposited:

16 Dec 2021 13:37

Last Modified:

19 Dec 2021 01:45

Publisher DOI:

10.1186/s12883-021-02502-3

PubMed ID:

34872509

Uncontrolled Keywords:

Encephalitis Meningitis Meningoencephalitis Sleep-wake disturbances Tick-borne encephalitis

BORIS DOI:

10.48350/162030

URI:

https://boris.unibe.ch/id/eprint/162030

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