Restless legs syndrome.

Manconi, Mauro; Garcia-Borreguero, Diego; Schormair, Barbara; Videnovic, Aleksandar; Berger, Klaus; Ferri, Raffaele; Dauvilliers, Yves (2021). Restless legs syndrome. Nature reviews. Disease Primers, 7(1), p. 80. Nature Publishing Group 10.1038/s41572-021-00311-z

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Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge to move that appears during rest or is exacerbated by rest, that occurs in the evening or night and that disappears during movement or is improved by movement. Symptoms vary considerably in age at onset, frequency and severity, with severe forms affecting sleep, quality of life and mood. Patients with RLS often display periodic leg movements during sleep or resting wakefulness. RLS is considered to be a complex condition in which predisposing genetic factors, environmental factors and comorbidities contribute to the expression of the disorder. RLS occurs alone or with comorbidities, for example, iron deficiency and kidney disease, but also with cardiovascular diseases, diabetes mellitus and neurological, rheumatological and respiratory disorders. The pathophysiology is still unclear, with the involvement of brain iron deficiency, dysfunction in the dopaminergic and nociceptive systems and altered adenosine and glutamatergic pathways as hypotheses being investigated. RLS is poorly recognized by physicians and it is accordingly often incorrectly diagnosed and managed. Treatment guidelines recommend initiation of therapy with low doses of dopamine agonists or α2δ ligands in severe forms. Although dopaminergic treatment is initially highly effective, its long-term use can result in a serious worsening of symptoms known as augmentation. Other treatments include opioids and iron preparations.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Manconi, Mauro


600 Technology > 610 Medicine & health




Nature Publishing Group




Chantal Kottler

Date Deposited:

16 Dec 2021 11:28

Last Modified:

05 Dec 2022 15:55

Publisher DOI:


PubMed ID:


Additional Information:

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