Page, Gonzague; Page, B.; Beltraminelli, H.; Borradori, L.; Schlapbach, C. (2021). Prurigo Pigmentosa: Demographics and Characteristics in 14 Caucasian Patients. Dermatology, 237(6), pp. 878-883. Karger 10.1159/000514026
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BACKGROUND
Prurigo pigmentosa (PP) is an inflammatory dermatosis typically reported in young Asian women and characterized by recurrent papulovesicular lesions resolving with a postinflammatory reticulated hyperpigmentation.
METHODS
We have included all consecutive patients with PP diagnosed in our tertiary center between 2013 and 2020. The clinical information was retrospectively collected from medical records.
RESULTS
We identified 14 patients with PP. The median age at the time of diagnosis was 29.5 years (range 17-43 years), while the female-to-male ratio was 13:1. Diagnostic delay varied from 10 days to 10 years (mean of 25 months). Light microscopy studies consistently showed presence of a lymphohistiocytic infiltrate in combination in 40% of cases with neutrophils. Interface changes were found in 60% of cases. In 6 (43%) of 14 cases, there was a chronological relationship between the starting of a new diet and the development of the first flares. Treatment with doxycycline in 9 patients resulted in a complete regression of the lesions.
LIMITATION
This was a retrospective study in a tertiary referral hospital.
CONCLUSIONS
Our observations indicate that PP is not so rare in Europe as previously thought and is often diagnosed after a long delay. Demographics, clinical characteristics and triggering factors in Caucasian patients are similar to those described in the Asian population. Diagnosis is based on the peculiar recurrent course and distinctive clinicopathological features. Tetracyclines represent the first-line therapy in PP.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Page, Basile, Beltraminelli, Helmut, Borradori, Luca, Schlapbach, Christoph |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1018-8665 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
05 Jan 2022 14:49 |
Last Modified: |
15 Jun 2023 12:01 |
Publisher DOI: |
10.1159/000514026 |
PubMed ID: |
33592602 |
Uncontrolled Keywords: |
Caucasian Diet Doxycycline Europe Prurigo pigmentosa Reticulated skin lesions |
BORIS DOI: |
10.48350/162118 |
URI: |
https://boris.unibe.ch/id/eprint/162118 |
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