Perioperative continuation of aspirin, oral anticoagulants or bridging with therapeutic low-molecular-weight heparin does not increase intraoperative blood loss and blood transfusion rate in cystectomy patients: an observational cohort study.

Furrer, Marc A; Abgottspon, Janine; Huber, Markus; Engel, Dominique; Löffel, Lukas M.; Beilstein, Christian M.; Burkhard, Fiona C.; Wüthrich, Patrick Y. (2022). Perioperative continuation of aspirin, oral anticoagulants or bridging with therapeutic low-molecular-weight heparin does not increase intraoperative blood loss and blood transfusion rate in cystectomy patients: an observational cohort study. BJU international, 129(4), pp. 512-523. Wiley 10.1111/bju.15599

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OBJECTIVE

To assess if uninterrupted anticoagulant agents' administration affects blood loss and blood transfusion during open radical cystectomy (RC) and urinary diversion.

PATIENTS AND METHODS

We conducted an observational single-centre cohort study of a consecutive series of 1430 RC patients, between 2000 and 2020. Blood loss was depicted according to body weight and duration of surgery (mL/kg/h), and blood transfusion. The group 'with anticoagulant agents' was considered if surgery was performed with uninterrupted low-dose aspirin (ASS), oral anticoagulants (OAC) with an international normalised ratio (INR) goal of 2-2.5 or bridging with therapeutic low-molecular-weight heparin (LMWH). Outcomes were intraoperative blood loss, blood transfusion rate (separately analysed if administered within 24 h perioperatively or >24 h after surgery) and the 90-day major adverse cardiac events (MACE) rate. We used propensity score (PS)-matching analysis to adjust for imbalances between groups with or without anticoagulant agents.

RESULTS

The PS-matched median (interquartile range [IQR]) blood loss was 2.10 (1.50-2.94) mL/kg/h in patients with anticoagulant agents vs 2.11 (1.47-2.94) mL/kg/h without anticoagulant agents (Padj  > 0.99). The PS-matched blood transfusion rates were 26.2% vs 35.1% (Padj  = 0.875) within 24 h perioperatively and 57.0% vs 55.0% (Padj  = 0.680) if administered >24 h postoperatively. A sub-analysis of the three different anticoagulant agents could not detect any significance between ASS, OAC, or LMWH. The PS-matched incidence of MACE was 9.1% in the group with anticoagulant agents and 8.1% in those without anticoagulant agents (Padj  > 0.99). Limitations include selection bias and retrospective analysis from prospectively assessed data.

CONCLUSIONS

Perioperative continuation of ASS, uninterrupted OAC with low INR goal or bridging with LMWH had no impact on blood loss and transfusion rate in RC patients. Therefore, there might be no compulsory need for discontinuation of anticoagulant agents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Huber, Markus, Engel, Dominique, Löffel, Lukas, Beilstein, Christian, Burkhard, Fiona Christine, Wüthrich, Patrick Yves

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1464-410X

Publisher:

Wiley

Language:

English

Submitter:

Khiem Duong

Date Deposited:

10 Dec 2021 13:28

Last Modified:

05 Dec 2022 15:56

Publisher DOI:

10.1111/bju.15599

PubMed ID:

34585829

Uncontrolled Keywords:

#BladderCancer #blcsm #uroonc anticoagulant agents anticoagulants aspirin bleeding blood transfusion cystectomy

BORIS DOI:

10.48350/162125

URI:

https://boris.unibe.ch/id/eprint/162125

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