Effect of topical application of platelet-rich plasma on chronic venous leg ulcerations.

Bossart, Simon; Seyed Jafari, S. Morteza; Lehmann, Mathias; Jossi-Will, Andreas; Sane, Esther; Heidemeyer, Kristine; Schorno, Petra; Pelloni, Lorenzo; Rammlmair, Anna; Schlapbach, Christoph (2022). Effect of topical application of platelet-rich plasma on chronic venous leg ulcerations. Dermatologic therapy, 35(2), e15236. Wiley 10.1111/dth.15236

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Wound products that reliably support healing of chronic leg ulcers remain a huge unmet need in clinical practice. Due to the lack of standardized comparable protocols and different systems for platelet-rich plasma (PRP) preparation, there is limited data on healing rates in chronic venous ulcers. In our case series with a total of seven chronic leg ulcers in four patients, we investigated the healing rates based on standardized digital photographs of chronic venous ulcers after application of topical PRP using a digital imaging software. In 5 out of 7 ulcers, the PRP-treated wound half showed faster healing as compared the control half of the wound. In this case series, PRP-treated sides of chronic venous leg ulcers showed a tendency for accelerated healing as compared to nontreated collateral wound side. Our data support the evaluation of topical PRP treatment in the management of chronic venous leg ulcers.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pathologie > Forschungsgruppe Dermatologie

UniBE Contributor:

Bossart, Simon, Jafari, Morteza, Lehmann, Mathias, Schorno, Petra Margrith, Rammlmair, Anna, Schlapbach, Christoph


600 Technology > 610 Medicine & health








Andrea Studer-Gauch

Date Deposited:

05 Jan 2022 16:03

Last Modified:

02 Mar 2023 23:35

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

PRP leg ulcer platelet-rich plasma ulcus cruris venous leg ulcerations





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