Brain Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review.

Matzaras, Rafail; Shi, Kuangyu; Artemiadis, Artemios; Zis, Panagiotis; Hadjigeorgiou, Georgios; Rominger, Axel; Bassetti, Claudio L.A.; Bargiotas, Panagiotis (2022). Brain Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease: A Systematic Review. Journal of Parkinson's disease, 12(1), pp. 69-83. IOS Press 10.3233/JPD-212571

Full text not available from this repository. (Request a copy)


REM-sleep behaviour disorder (RBD) is a parasomnia and a common comorbidity in Parkinson's disease (PD). There is evidence that the presence of RBD is associated with more severe PD. The differences in the clinical manifestations and the natural history are likely to imply underlying differences in the pathophysiology among PD patients with and without RBD. The increasing number of neuroimaging studies support this notion.


Our primary objective was to review the current evidence regarding the brain neuroimaging findings in PD patients with RBD (PDRBD).


A systematic review of articles, published in PubMed between January 1, 2000 and September 23, 2020 was performed. We evaluate previous studies that assessed PD patients with RBD using various brain structural and functional magnetic resonance imaging (MRI) techniques and brain nuclear medicine imaging.


Twenty-nine studies, involving a total of 3,347 PD subjects among which 912 subjects with PDRBD, met the selection criteria and were included. The presence of RBD in PD patients is associated with structural and functional alterations in several brain regions, mainly in brainstem, limbic structures, frontotemporal cortex, and basal ganglia, raising the hypothesis of a PDRBD neuroimaging phenotype.


The current review provides up-to-date knowledge in this field and summarizes the neurobiological/neuroimaging substrate of RBD in PD.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Shi, Kuangyu, Rominger, Axel Oliver, Bassetti, Claudio L.A.


600 Technology > 610 Medicine & health




IOS Press




Chantal Kottler

Date Deposited:

20 Dec 2021 14:23

Last Modified:

05 Dec 2022 15:56

Publisher DOI:


PubMed ID:


Additional Information:

Kein Zugriff auf Manuskript

Uncontrolled Keywords:

Parkinson’s disease RBD diffusion tensor imaging functional neuroimaging neuromelanin-sensitive MRI nuclear medicine imaging positron emission tomography single photon emission computed tomography structural MRI voxel-based morphometry


Actions (login required)

Edit item Edit item
Provide Feedback