Different stages in drug development for muscle-invasive bladder cancer.

Ineichen, Gallus Beatus; Röthlisberger, Raphael; Johner, Kevin Fabian; Seiler, Roland (2017). Different stages in drug development for muscle-invasive bladder cancer. Translational andrology and urology, 6(6), pp. 1060-1066. AME Publishing Company 10.21037/tau.2017.11.22

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Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease. Despite optimal therapy, half of the patients will succumb to disease. This prognosis could not be improved over the last three decades. Therefore, MIBC is left behind from other cancers such as prostate, where novel treatment options were discovered and improve patient outcomes. While being aware of the recent emerging evidence of checkpoint inhibition in MIBC, we aim to describe different stages of drug development in MIBC by using three specific targets. On the example of Her2 targeting, we aimed to indicate, that either a target is ineffective in MIBC or that the patient selection is insufficient. The first clinical trials using a pan fibroblast growth factor receptor (panFGFR) inhibitor to target the FGFR pathway showed promising results. Data of further trials are to be awaited before implementing these drugs into daily clinical practice. A large variety of novel agents are investigated in vitro and in vivo. On the example of a malaria protein, we aimed to discuss a treatment paradigm that is not dependent on pathway signaling and the genomic landscape of MIBC. The ultimate question still remains to be answered: How do we select the optimal treatment for the right patient?

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Ineichen, Gallus Beatus; Röthlisberger, Raphael; Johner, Kevin and Seiler-Blarer, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2223-4683

Publisher:

AME Publishing Company

Language:

English

Submitter:

Khiem Duong

Date Deposited:

10 Jan 2022 12:44

Last Modified:

10 Jan 2022 12:44

Publisher DOI:

10.21037/tau.2017.11.22

PubMed ID:

29354493

Uncontrolled Keywords:

Bladder cancer drug development patient selection targeted therapies

BORIS DOI:

10.48350/162218

URI:

https://boris.unibe.ch/id/eprint/162218

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