Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review.

Giudici, Nicola; Bonne, Fieke; Blarer, Jennifer; Minoli, Martina; Friedemann Krentel, Andreas; Seiler, Roland (2021). Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review. Translational andrology and urology, 10(10), pp. 4036-4050. AME Publishing Company 10.21037/tau-20-1472

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Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the two locations seem to be apparent and may question in handling them as a single oncologic entity. In this review we discuss similarities and differences between bladder and upper urinary tract UC and consider their potential impact on treatment strategies. Despite similarities of UC in the bladder (BC) and the upper urinary tract (UTUC), clinicopathologic and molecular differences may question to generally assemble both as a single tumor entity. Treatment standards for UTUC are often adopted from BC. However, a specific investigation in the former may still be meaningful as shown by the example of adjuvant cisplatin based chemotherapy. In conclusion, future investigations should prioritize the understanding of the tumor biology of both BC and UTUC. This may reveal which UTUC can be treated according to treatment standards of BC and in which cases, a separate approach may be more appropriate.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Giudici, Nicola Gabriele, Minoli, Martina, Friedemann Krentel, Andreas, Seiler-Blarer, Roland


600 Technology > 610 Medicine & health




AME Publishing Company




Khiem Duong

Date Deposited:

10 Jan 2022 12:41

Last Modified:

05 Dec 2022 15:56

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Urothelial carcinomas (UC) bladder cancer upper urinary tract




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