Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain.

Benedé-Ubieto, Raquel; Estévez-Vázquez, Olga; Flores-Perojo, Vicente; Macías-Rodríguez, Ricardo U; Ruiz-Margáin, Astrid; Martínez-Naves, Eduardo; Regueiro, José R; Ávila, Matías A; Trautwein, Christian; Bañares, Rafael; Bosch, Jaime; Cubero, Francisco Javier; Nevzorova, Yulia A (2021). Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. Journal of clinical medicine, 10(5) MDPI 10.3390/jcm10051039

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The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Bosch, Jaime

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2077-0383

Publisher:

MDPI

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

29 Dec 2021 14:31

Last Modified:

29 Dec 2021 14:31

Publisher DOI:

10.3390/jcm10051039

PubMed ID:

33802486

Uncontrolled Keywords:

AST/ALT ratio SARS-CoV-2 ferritin liver injury pandemic

BORIS DOI:

10.48350/162229

URI:

https://boris.unibe.ch/id/eprint/162229

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