Kontopoulou, Konstantina; Ainatzoglou, Alexandra; Ifantidou, Athina; Nakas, Christos T.; Gkounti, Georgia; Adamopoulos, Vasilios; Papadopoulos, Nikitas; Papazisis, Georgios (2021). Immunogenicity after the first dose of the BNT162b2 mRNA Covid-19 vaccine: real-world evidence from Greek healthcare workers. Journal of medical microbiology, 70(8) SGM 10.1099/jmm.0.001387
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Real-world data regarding the effectiveness, safety and immunogenicity of the Pfizer-BioNTech BNT162b2 mRNA vaccine are accumulating in the literature, suggesting that this vaccine generates high titres of S1-binding IgG antibodies that exhibit potent virus neutralization capacity. This is the first phase IV immunogenicity study to recruit a large number of Greek healthcare workers (n=425) including 63 previously-infected subjects. We measured titres of neutralizing IgGs against the receptor-binding domain of the S1 subunit of the spike protein of SARS-CoV-2 14 days post-immunization with the first dose, employing the SARS-CoV-2 IgG II Quant assay. A total of 92.24 % of our study cohort received a positive assay outcome and titres varied with age. Post-hoc analysis revealed that although titres did not significantly differ among participants aged 20-49 years, a significant decline was marked in the age group of 50-59 years, which was further accentuated in subjects aged over 60. Antibody titres escalated significantly among the previously-infected, indicating the potential booster effect of the first dose in that group.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Nakas, Christos T. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-2615 |
Publisher: |
SGM |
Language: |
English |
Submitter: |
Karin Balmer |
Date Deposited: |
12 Jan 2022 15:31 |
Last Modified: |
05 Dec 2022 15:56 |
Publisher DOI: |
10.1099/jmm.0.001387 |
PubMed ID: |
34397348 |
BORIS DOI: |
10.48350/162275 |
URI: |
https://boris.unibe.ch/id/eprint/162275 |
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