Bauckneht, Matteo; Chincarini, Andrea; Brendel, Matthias; Rominger, Axel; Beyer, Leonie; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G.; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni B.; Lemstra, Afina W.; Berckel, Bart N. M.; Pilotto, Andrea; Padovani, Alessandro; Ochoa‐Figueroa, Miguel A.; Davidsson, Anette; Camacho, Valle; Peira, Enrico; ... (2021). Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European‐DLB consortium project. Alzheimer's & dementia, 17(8), pp. 1277-1286. Wiley 10.1002/alz.12294
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Alzheimer_s___Dementia_-_2021_-_Bauckneht_-_Associations_among_education__age__and_the_dementia_with_Lewy_bodies__DLB_.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) |
Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern.
Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age).
Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent).
Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1552-5260 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Daria Vogelsang |
Date Deposited: |
13 Jan 2022 09:46 |
Last Modified: |
05 Dec 2022 15:56 |
Publisher DOI: |
10.1002/alz.12294 |
PubMed ID: |
33528089 |
BORIS DOI: |
10.48350/162346 |
URI: |
https://boris.unibe.ch/id/eprint/162346 |
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