Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European‐DLB consortium project

Bauckneht, Matteo; Chincarini, Andrea; Brendel, Matthias; Rominger, Axel; Beyer, Leonie; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G.; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni B.; Lemstra, Afina W.; Berckel, Bart N. M.; Pilotto, Andrea; Padovani, Alessandro; Ochoa‐Figueroa, Miguel A.; Davidsson, Anette; Camacho, Valle; Peira, Enrico; ... (2021). Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European‐DLB consortium project. Alzheimer's & dementia, 17(8), pp. 1277-1286. Wiley 10.1002/alz.12294

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Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern.

Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age).

Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent).

Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1552-5260

Publisher:

Wiley

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

13 Jan 2022 09:46

Last Modified:

13 Jan 2022 09:46

Publisher DOI:

10.1002/alz.12294

PubMed ID:

33528089

BORIS DOI:

10.48350/162346

URI:

https://boris.unibe.ch/id/eprint/162346

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