Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis; Bron, Dominique; Capasso, Antonella; Chatzileontiadou, Sofia; Cordoba, Raul; Correa, Juan-Gonzalo; Cuéllar-García, Carolina; De Paoli, Lorenzo; De Paolis, Maria Rosaria; Del Poeta, Giovanni; Demosthenous, Christos; ... (2021). COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia, 35(12), pp. 3444-3454. Springer Nature 10.1038/s41375-021-01450-8
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CO4_-_COVID-19_severity_and_mortality_in_CLL_update_-_Leukemia_2021.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Andres, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0887-6924 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pierrette Durand Lüthi |
Date Deposited: |
10 Jan 2022 10:11 |
Last Modified: |
05 Dec 2022 15:57 |
Publisher DOI: |
10.1038/s41375-021-01450-8 |
PubMed ID: |
34725454 |
BORIS DOI: |
10.48350/162477 |
URI: |
https://boris.unibe.ch/id/eprint/162477 |
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