Mapping covariance in brain FDG uptake to structural connectivity.

Yakushev, Igor; Ripp, Isabelle; Wang, Min; Savio, Alex; Schutte, Michael; Lizarraga, Aldana; Bogdanovic, Borjana; Diehl-Schmid, Janine; Hedderich, Dennis M; Grimmer, Timo; Shi, Kuangyu (2022). Mapping covariance in brain FDG uptake to structural connectivity. European journal of nuclear medicine and molecular imaging, 49(4), pp. 1288-1297. Springer 10.1007/s00259-021-05590-y

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PURPOSE

Inter-subject covariance of regional 18F-fluorodeoxyglucose (FDG) PET measures (FDGcov) as proxy of brain connectivity has been gaining an increasing acceptance in the community. Yet, it is still unclear to what extent FDGcov is underlied by actual structural connectivity via white matter fiber tracts. In this study, we quantified the degree of spatial overlap between FDGcov and structural connectivity networks.

METHODS

We retrospectively analyzed neuroimaging data from 303 subjects, both patients with suspected neurodegenerative disorders and healthy individuals. For each subject, structural magnetic resonance, diffusion tensor imaging, and FDG-PET data were available. The images were spatially normalized to a standard space and segmented into 62 anatomical regions using a probabilistic atlas. Sparse inverse covariance estimation was employed to estimate FDGcov. Structural connectivity was measured by streamline tractography through fiber assignment by continuous tracking.

RESULTS

For the whole brain, 55% of detected connections were found to be convergent, i.e., present in both FDGcov and structural networks. This metric for random networks was significantly lower, i.e., 12%. Convergent were 80% of intralobe connections and only 30% of interhemispheric interlobe connections.

CONCLUSION

Structural connectivity via white matter fiber tracts is a relevant substrate of FDGcov, underlying around a half of connections at the whole brain level. Short-range white matter tracts appear to be a major substrate of intralobe FDGcov connections.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Shi, Kuangyu

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1619-7089

Publisher:

Springer

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

10 Jan 2022 10:23

Last Modified:

16 Mar 2022 00:12

Publisher DOI:

10.1007/s00259-021-05590-y

PubMed ID:

34677627

Uncontrolled Keywords:

Diffusion tensor imaging FDG-PET Networks Positron emission tomography Tractography

BORIS DOI:

10.48350/162493

URI:

https://boris.unibe.ch/id/eprint/162493

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