Exploration of the efficacy of radiomics applied to left ventricular tomograms obtained from D-SPECT MPI for the auxiliary diagnosis of myocardial ischemia in CAD.

Wang, Junpeng; Fan, Xin; Qin, ShanShan; Shi, Kuangyu; Zhang, Han; Yu, Fei (2022). Exploration of the efficacy of radiomics applied to left ventricular tomograms obtained from D-SPECT MPI for the auxiliary diagnosis of myocardial ischemia in CAD. The international journal of cardiovascular imaging, 38(2), pp. 465-472. Springer 10.1007/s10554-021-02413-x

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To explore the feasibility and efficacy of radiomics with left ventricular tomograms obtained from D-SPECT myocardial perfusion imaging (MPI) for auxiliary diagnosis of myocardial ischemia in coronary artery disease (CAD). The images of 103 patients with CAD myocardial ischemia between September 2020 and April 2021 were retrospectively selected. After information desensitization processing, format conversion, annotation using the Labelme tool on an open-source platform, lesion classification, and establishment of a database, the images were cropped for analysis. The ResNet18 model was used to automate two steps (classification and segmentation) with five randomization, training and validation steps. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, positive predictive value, negative predictive value, Youden's index, agreement rate, and kappa value were calculated as evaluation indexes of the classification results for each training-validation step; then, receiver operating characteristics (ROC) curves were drawn, and the areas under the curve (AUCs) were calculated. The Dice coefficient, intersection over union, and Hausdorff distance were calculated as evaluation indexes of the segmentation results for each training-validation step; then, the predicted images were exported. Under the existing conditions, the radiomics model used in this study had an AUC above 0.95 in identifying the presence or absence of myocardial ischemia; in the prediction of the extent of myocardial ischemia, its evaluation index distribution is also close to that of the gold standard. Radiomics can be feasibly applied to left ventricular tomograms obtained from D-SPECT MPI for auxiliary diagnosis. With more in-depth research and the development of technology, adding this method to the existing auxiliary diagnosis will likely further improve the diagnostic accuracy and efficiency, and patients will therefore benefit.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Shi, Kuangyu

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1875-8312

Publisher:

Springer

Language:

English

Submitter:

Daria Vogelsang

Date Deposited:

11 Jan 2022 09:51

Last Modified:

04 Mar 2022 00:12

Publisher DOI:

10.1007/s10554-021-02413-x

PubMed ID:

34591200

Uncontrolled Keywords:

D-SPECT Left ventricular tomograms Myocardial perfusion imaging Radiomics

BORIS DOI:

10.48350/162496

URI:

https://boris.unibe.ch/id/eprint/162496

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