Mariano Faggion, Clovis; Menne, Max Clemens; Pandis, Nikolaos (2021). Prediction intervals should be included in meta-analyses published in dentistry. European journal of oral sciences, 129(6), e12827. Wiley-Blackwell 10.1111/eos.12827
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This focus article aims to highlight the value of reporting prediction intervals (PIs) in random effects meta-analysis and to assess the prevalence of PI-reporting in periodontology and implant dentistry meta-analyses. We searched in the PubMed database for meta-analyses published in the fields of periodontology and implant dentistry. We selected meta-analyses related to primary outcomes with at least three trials. Additionally, we extracted information on the type of the meta-analysis model (fixed or random) and whether the random effects meta-analyses included PIs in addition to the 95% confidence intervals. Three-hundred and forty-nine meta-analyses were found in 94 systematic reviews. Two-hundred and sixty-three (75.4%) subgroup and full meta-analyses used the random-effects model, 81 (23.2%) used fixed-effect methods, and 5 (1.4%) did not specify the model used. In 75 systematic reviews, we found 231 meta-analyses with three or more trials (173 full meta-analyses and 58 subgroup meta-analyses). Only one systematic review reported PIs. Interpretation of the results of random effects meta-analyses which ignore heterogeneity can be misleading. Heterogeneity should be explored, and two common approaches include subgroup analyses and meta-regression. Random effects meta-analyses should include PIs because they convey the extent of heterogeneity in treatment effects across studies in a clinically relevant context.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Pandis, Nikolaos |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0909-8836 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Renate Imhof-Etter |
Date Deposited: |
03 Jan 2022 15:53 |
Last Modified: |
05 Dec 2022 15:57 |
Publisher DOI: |
10.1111/eos.12827 |
PubMed ID: |
34865260 |
Uncontrolled Keywords: |
confidence intervals meta-analysis methods prediction intervals research design |
BORIS DOI: |
10.48350/162576 |
URI: |
https://boris.unibe.ch/id/eprint/162576 |
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