Laser-Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split-Face Study in France.

Benzaquen, Michael; Fongue, Jessica; Pauly, Vanessa; Collet-Villette, Anne-Marie (2021). Laser-Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split-Face Study in France. Lasers in surgery and medicine, 53(9), pp. 1166-1172. Wiley 10.1002/lsm.23403

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BACKGROUND AND OBJECTIVES

Combining the efficacy of ablative fractional carbon dioxide lasers (AFXL) to laser-assisted hyaluronic acid delivery (LAHAD) has not yet been studied. The objective of our study was to evaluate the safety and the efficacy of laser-assisted hyaluronic acid (HA) delivery with AFXL in facial skin remodeling.

STUDY DESIGN/MATERIALS AND METHODS

We conducted a prospective, double-blinded, randomized split-face study on 20 patients from 30 to 70 years old, with a skin phototype from I to IV. Each patient received full-face treatment with AFXL, immediately followed by the application in droplets into the fractional ablative tunnels of 1 ml of HA gel on one hemiface and 1 ml of physiological saline on the other hemiface. To evaluate postlaser aftermath, the intensity of erythema, edema, and crusts was graded. To assess facial skin remodeling, we scored the improvement of skin texture, firmness, fine lines, and skin radiance from baseline. Patients were evaluated on the 3rd and 7th day, 1st and 3rd month using clinical evaluations, photographs, and patient questionnaires.

RESULTS

We showed equivalence in postlaser aftermath between HA-treated and nontreated hemiface. Trend data analyses at the 3rd month suggested that immediate application of HA after AFXL resulted in a greater improvement in facial skin remodeling, especially for skin texture (mean score of 2.60 vs. 2.45) and skin firmness (mean score of 2.55 vs. 2.40). Skin radiance showed the best improvement, reaching almost a score of 5/10.

CONCLUSIONS

LAHAD with AFXL is a safe treatment showing promising results in facial skin remodeling. These findings need to be confirmed by a larger study to evaluate the value of LAHAD in daily clinical practice. Lasers Surg. Med. © 2021 Wiley Periodicals LLC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Benzaquen, Michael Joseph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1096-9101

Publisher:

Wiley

Language:

English

Submitter:

Andrea Studer-Gauch

Date Deposited:

12 Jan 2022 14:45

Last Modified:

05 Dec 2022 15:57

Publisher DOI:

10.1002/lsm.23403

PubMed ID:

33792961

Uncontrolled Keywords:

fractional carbon dioxide laser hyaluronic acid laser-assisted delivery photodamaged skin postlaser aftermath skin remodeling

BORIS DOI:

10.48350/162579

URI:

https://boris.unibe.ch/id/eprint/162579

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