Polarimetric visualization of healthy brain fiber tracts under adverse conditions: ex vivo studies.

Rodríguez-Núñez, Omar; Schucht, Philippe; Hewer, Ekkehard; Novikova, Tatiana; Pierangelo, Angelo (2021). Polarimetric visualization of healthy brain fiber tracts under adverse conditions: ex vivo studies. Biomedical optics express, 12(10), pp. 6674-6685. Optical Society of America 10.1364/BOE.439754

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We suggest using the wide-field imaging Mueller polarimetry to contrast optically anisotropic fiber tracts of healthy brain white matter for the detection of brain tumor borders during neurosurgery. Our prior studies demonstrate that this polarimetric imaging modality detects correctly the in-plane orientation of brain white matter fiber tracts of a flat formalin-fixed thick brain specimen in reflection geometry [IEEE Trans. Med. Imaging39, 4376 (2020)10.1109/TMI.2020.3018439]. Here we present the results of ex vivo polarimetric studies of large cross-sections of fresh calf brain in reflection geometry with a special focus on the impact of the adverse measurement conditions (e.g. complex surface topography, presence of blood, etc.) on the quality of polarimetric images and the detection performance of white matter fiber tracts and their in-plane orientation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Schucht, Philippe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2156-7085

Publisher:

Optical Society of America

Language:

English

Submitter:

Nicole Söll

Date Deposited:

20 Jan 2022 09:32

Last Modified:

05 Dec 2022 15:58

Publisher DOI:

10.1364/BOE.439754

PubMed ID:

34745764

BORIS DOI:

10.48350/162697

URI:

https://boris.unibe.ch/id/eprint/162697

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