Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain

Kasanetz, Fernando; Nevian, Thomas (2021). Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain. Scientific reports, 11(1), p. 24240. Springer Nature 10.1038/s41598-021-03652-7

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Neuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Kasanetz, Fernando and Nevian, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Stefan von Känel-Zimmermann

Date Deposited:

11 Jan 2022 16:09

Last Modified:

16 Jan 2022 01:56

Publisher DOI:

10.1038/s41598-021-03652-7

PubMed ID:

34930957

BORIS DOI:

10.48350/162789

URI:

https://boris.unibe.ch/id/eprint/162789

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