Antivitamins - General views

Schopfer, Wiliam Henri (1953). Antivitamins - General views. La ricerca scientifica, 23(4). Roma: Consiglio nazionale delle ricerche

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The antivitamins are specific competitive antagonists of the vitamins. Their effect
exists in displacing the latter, tlms troubling the activity of enzymes of which the vitamins
are the coenzymes. The thus implied blocking of metabolic processes has deep repercussive cffects which go further than a simple displacement: perturbations in the biosynthesis
of certain acids, of purines, nucleic acids and other essential metabolic products are relieved_
By means of certain microorganisms it can be shown that not only the specific vitamin
correspondent to the utilized antivitamin is displaced but that the whole vitamin balance
of the organism is disturbed.
The antivitamins are not only important for therapeutical purposes, they are also
of an important value of metabolic investigations

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