Crichton, Megan L; Goeminne, Pieter C; Tuand, Krizia; Vandendriessche, Thomas; Tonia, Thomy; Roche, Nicolas; Chalmers, James D (2021). The impact of therapeutics on mortality in hospitalised patients with COVID-19: systematic review and meta-analyses informing the European Respiratory Society living guideline. European respiratory review, 30(162), p. 210171. European Respiratory Society 10.1183/16000617.0171-2021
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Hospitalised patients with coronavirus disease 2019 (COVID-19) have a high mortality rate. There are an increasing number of published randomised controlled trials for anti-inflammatory, anti-viral and other treatments. The European Respiratory Society Living Guidelines for the Management of Hospitalised Adults with COVID-19 were published recently, providing recommendations on appropriate pharmacotherapy.Patient, Intervention, Comparator and Outcomes questions for key interventions were identified by an international panel and systematic reviews were conducted to identify randomised controlled trials meeting the inclusion criteria. The importance of end-points were rated, and mortality was identified as the key "critical" outcome for all interventions. Random-effects meta-analysis was used to pool studies and provide effect estimates for the impact of treatments on mortality.Corticosteroids, hydroxychloroquine, azithromycin, remdesivir, anti-interleukin (IL)-6 monoclonal antibodies, colchicine, lopinavir/ritonavir and interferon-β have been reviewed.Our results found further evidence in support of the use of corticosteroids, particularly dexamethasone, and anti-IL-6 receptor monoclonal antibody therapy. These data support the need to identify additional therapies with beneficial effects on mortality.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Tonia, Thomai |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0905-9180 |
Publisher: |
European Respiratory Society |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
21 Dec 2021 18:45 |
Last Modified: |
03 Jan 2023 09:44 |
Publisher DOI: |
10.1183/16000617.0171-2021 |
PubMed ID: |
34911695 |
BORIS DOI: |
10.48350/162931 |
URI: |
https://boris.unibe.ch/id/eprint/162931 |
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