Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study.

Masselot, Pierre; Sera, Francesco; Schneider, Rochelle; Kan, Haidong; Lavigne, Éric; Stafoggia, Massimo; Tobias, Aurelio; Chen, Hong; Burnett, Richard T; Schwartz, Joel; Zanobetti, Antonella; Bell, Michelle L; Chen, Bing-Yu; Leon Guo, Yue-Liang; Ragettli, Martina S; Vicedo-Cabrera, Ana Maria; Åström, Christofer; Forsberg, Bertil; Íñiguez, Carmen; Garland, Rebecca M; ... (2022). Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study. Epidemiology, 33(2), pp. 167-175. Wolters Kluwer Health, Lippincott Williams & Wilkins 10.1097/EDE.0000000000001455

Preview	Text Masselot_Epidemiology_2021_AAM.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (1MB) | Preview
	Text Masselot_Epidemiology_2022.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) | Request a copy

BACKGROUND

The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality.

METHODS

We applied a two-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators.

RESULTS

We found associations between RR and several PM2.5 components. Increasing the ammonium (NH4+) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95%CI: 1.0030-1.0097) to 1.0102 (95%CI:1.0070-1.0135). Conversely, an increase in nitrate (NO3-) from 1% to 71% resulted in a reduced RR, from 1.0100 (95%CI: 1.0067-1.0133) to 1.0037 (95%CI: 0.9998- 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk.

CONCLUSIONS

These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.

Interest & Impact

Downloads

102 since deposited on 21 Dec 2021
101 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item