Smailovic, Una; Kåreholt, Ingemar; Koenig, Thomas; Ashton, Nicholas J; Winblad, Bengt; Höglund, Kina; Nilsson, Per; Zetterberg, Henrik; Blennow, Kaj; Jelic, Vesna (2021). Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's Disease. Journal of Alzheimer's disease, 83(1), pp. 355-366. IOS Press 10.3233/JAD-201234
|
Text
jad_2021_83-1_jad-83-1-jad201234_jad-83-jad201234.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (252kB) | Preview |
BACKGROUND
Cerebrospinal fluid (CSF) neurogranin and quantitative electroencephalography (qEEG) are potential molecular and functional markers of synaptic pathology in Alzheimer's disease (AD). Synaptic markers have emerged as candidate prognostic indicators of AD since synaptic degeneration was shown to be an early event and the best correlate of cognitive deficits in patients along the disease continuum.
OBJECTIVE
The present study investigated the association between CSF neurogranin and qEEG measures as well as their potential to predict clinical deterioration in mild cognitive impairment (MCI) patients.
METHODS
Patients diagnosed with MCI (n = 99) underwent CSF conventional AD biomarkers and neurogranin analysis and resting-state EEG recordings. The study population was further stratified into stable (n = 41) and progressive MCI (n = 31), based on the progression to AD dementia during two years follow-up. qEEG analysis included computation of global field power and global field synchronization in four conventional frequency bands.
RESULTS
CSF neurogranin levels were associated with theta power and synchronization in the progressive MCI group. CSF neurogranin and qEEG measures were significant predictors of progression to AD dementia, independent of baseline amyloid status in MCI patients. A combination of CSF neurogranin with global EEG power in theta and global EEG synchronization in beta band exhibited the highest classification accuracy as compared to either of these markers alone.
CONCLUSION
qEEG and CSF neurogranin are independent predictors of progression to AD dementia in MCI patients. Molecular and neurophysiological synaptic markers may have additive value in a multimodal diagnostic and prognostic approach to dementia.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center |
UniBE Contributor: |
König, Thomas |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1387-2877 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Thomas König |
Date Deposited: |
18 Jan 2022 09:34 |
Last Modified: |
05 Dec 2022 15:58 |
Publisher DOI: |
10.3233/JAD-201234 |
PubMed ID: |
34334389 |
Uncontrolled Keywords: |
synaptic markers Alzheimer’s disease cerebrospinal fluid mild cognitive impairment neurogranin prognostic markers quantitative electroencephalography |
BORIS DOI: |
10.48350/162961 |
URI: |
https://boris.unibe.ch/id/eprint/162961 |
Actions (login required)
 |
Edit item |