Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer's Disease Patients-Relationship to APOE ε4.

Smailovic, Una; Johansson, Charlotte; Koenig, Thomas; Kåreholt, Ingemar; Graff, Caroline; Jelic, Vesna (2021). Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer's Disease Patients-Relationship to APOE ε4. Brain Sciences, 11(10) MDPI 10.3390/brainsci11101359

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The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD) that has been linked to changes in brain structure and function as well as to different biological subtypes of the disease. The present study aimed to investigate the association of APOE ε4 genotypes with brain functional impairment, as assessed by quantitative EEG (qEEG) in patients on the AD continuum. The study population included 101 amyloid positive patients diagnosed with mild cognitive impairment (MCI) (n = 50) and AD (n = 51) that underwent resting-state EEG recording and CSF Aβ42 analysis. In total, 31 patients were APOE ε4 non-carriers, 42 were carriers of one, and 28 were carriers of two APOE ε4 alleles. Quantitative EEG analysis included computation of the global field power (GFP) and global field synchronization (GFS) in conventional frequency bands. Amyloid positive patients who were carriers of APOE ε4 allele(s) had significantly higher GFP beta and significantly lower GFS in theta and beta bands compared to APOE ε4 non-carriers. Increased global EEG power in beta band in APOE ε4 carriers may represent a brain functional compensatory mechanism that offsets global EEG slowing in AD patients. Our findings suggest that decreased EEG measures of global synchronization in theta and beta bands reflect brain functional deficits related to the APOE ε4 genotype in patients that are on a biomarker-verified AD continuum.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2076-3425

Publisher:

MDPI

Language:

English

Submitter:

Thomas König

Date Deposited:

18 Jan 2022 09:26

Last Modified:

08 Nov 2022 05:40

Publisher DOI:

10.3390/brainsci11101359

PubMed ID:

34679423

Uncontrolled Keywords:

Alzheimer’s disease amyloid pathology apolipoprotein E mild cognitive impairment quantitative electroencephalography

BORIS DOI:

10.48350/162963

URI:

https://boris.unibe.ch/id/eprint/162963

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