The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H

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pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Cai, Xingguang; Javor, Sacha; Gan, Bee Ha and Reymond, Jean-Louis

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1359-7345

Publisher:

Royal Society of Chemistry

Language:

English

Submitter:

Sandra Tanja Zbinden Di Biase

Date Deposited:

19 Jan 2022 15:20

Last Modified:

05 Dec 2022 15:59

Publisher DOI:

10.1039/D1CC01838H

PubMed ID:

33972964

BORIS DOI:

10.48350/163002

URI:

https://boris.unibe.ch/id/eprint/163002

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