Erzina, Dina; Capecchi, Alice; Javor, Sacha; Reymond, Jean-Louis (2021). An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate. Angewandte Chemie International Edition, 60(50), pp. 26403-26408. Wiley 10.1002/anie.202113562
|
Text
Angewandte_Chemie_Intl_Edit_-_2021_-_Erzina_-_An_Immunomodulatory_Peptide_Dendrimer_Inspired_from_Glatiramer_Acetate.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
To identify an alternative to the polymeric peptide drug Glatiramer Acetate (GA) used to treat multiple sclerosis, we tested peptide dendrimers with a size and composition similar to that of GA for their ability to induce the release of the cytokine IL1-Ra from primary human monocytes. The best dendrimer is as active as GA and is shown by fluorescence labelling to internalize into monocytes and to trigger a distinct anti-inflammatory response.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Erzina, Dina, Capecchi, Alice, Javor, Sacha, Reymond, Jean-Louis |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1433-7851 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Sandra Tanja Zbinden Di Biase |
Date Deposited: |
19 Jan 2022 15:26 |
Last Modified: |
05 Dec 2022 15:59 |
Publisher DOI: |
10.1002/anie.202113562 |
PubMed ID: |
34618395 |
BORIS DOI: |
10.48350/163013 |
URI: |
https://boris.unibe.ch/id/eprint/163013 |
Actions (login required)
 |
Edit item |