An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate

Erzina, Dina; Capecchi, Alice; Javor, Sacha; Reymond, Jean-Louis (2021). An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate. Angewandte Chemie International Edition, 60(50), pp. 26403-26408. Wiley 10.1002/anie.202113562

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To identify an alternative to the polymeric peptide drug Glatiramer Acetate (GA) used to treat multiple sclerosis, we tested peptide dendrimers with a size and composition similar to that of GA for their ability to induce the release of the cytokine IL1-Ra from primary human monocytes. The best dendrimer is as active as GA and is shown by fluorescence labelling to internalize into monocytes and to trigger a distinct anti-inflammatory response.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Erzina, Dina; Capecchi, Alice; Javor, Sacha and Reymond, Jean-Louis

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1433-7851

Publisher:

Wiley

Language:

English

Submitter:

Sandra Tanja Zbinden Di Biase

Date Deposited:

19 Jan 2022 15:26

Last Modified:

05 Dec 2022 15:59

Publisher DOI:

10.1002/anie.202113562

PubMed ID:

34618395

BORIS DOI:

10.48350/163013

URI:

https://boris.unibe.ch/id/eprint/163013

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