Dietary factors and onset of natural menopause: a systematic review and meta-analysis.

Grisotto, Giorgia; Farago, Julian S.; Taneri, Petek E.; Wehrli, Faina; Roa Díaz, Zayne M.; Minder, Beatrice; Glisic, Marija; Gonzalez-Jaramillo, Valentina; Voortman, Trudy; Marques-Vidal, Pedro; Franco, Oscar H.; Muka, Taulant (2022). Dietary factors and onset of natural menopause: a systematic review and meta-analysis. Maturitas, 159, pp. 15-32. Elsevier 10.1016/j.maturitas.2021.12.008

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Diet has been suggested to play a role in determining the age at natural menopause; however, the evidence is inconsistent.


We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM).


We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of Science and Google Scholar) through January 21,2021 to identify prospective studies assessing the association between diet and ONM. Two independent reviewers extracted data using a predesigned data-collection form. Pooled hazard risks (HRs) were calculated using random effect models.


Of the 6,137 eligible references we reviewed, we included 15 articles in our final analysis. Those 15 articles included 91,554 women out of 298,413 who experienced natural menopause during follow-up. Overall, there were 89 food groups investigated, 38 macronutrients and micronutrients, and 6 dietary patterns. Among the food groups, higher intake of green and yellow vegetables was associated with earlier age of ONM, while high intakes of some dairy products, such as low-fat, skimmed milk, and low intake of alcohol were associated with a later onset. We observed no consistent association between macronutrient and micronutrient intake and ONM. Our results suggests that a vegetarian diet could be associated with early ONM; we did not observe any other consistent effect from other dietary patterns. Limitations included the number of studies, lack of replication studies and the research being of an observational nature; most studies (11/15) were at medium risk of bias.


Although some food items were associated with ONM, the overall evidence about associations between diet and ONM remains controversial.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
13 Central Units > Administrative Director's Office > University Library of Bern

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Grisotto, Giorgia, Taneri, Petek Eylul, Wehrli, Faina, Roa Diaz, Zayne Milena, Minder, Beatrice, Glisic, Marija, Gonzalez Jaramillo, Valentina, Franco Duran, Oscar Horacio, Muka, Taulant


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
000 Computer science, knowledge & systems > 020 Library & information sciences








Doris Kopp Heim

Date Deposited:

22 Dec 2021 19:21

Last Modified:

27 Dec 2022 10:47

Publisher DOI:


PubMed ID:





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