Increased Impact of Air Pollution on Lung Function in Preterm vs. Term Infants: The BILD Study.

Decrue, Fabienne; Gorlanova, Olga; Salem, Yasmin; Vienneau, Danielle; de Hoogh, Kees; Gisler, Amanda; Usemann, Jakob; Korten, Insa; Nahum, Uri; Sinues, Pablo; Schulzke, Sven; Fuchs, Oliver; Latzin, Philipp; Röösli, Martin; Frey, Urs (2022). Increased Impact of Air Pollution on Lung Function in Preterm vs. Term Infants: The BILD Study. American journal of respiratory and critical care medicine, 205(1), pp. 99-107. American Thoracic Society 10.1164/rccm.202102-0272OC

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Rationale Infants born prematurely have impaired capacity to deal with oxidative stress shortly after birth. Objectives We hypothesize that the relative impact of exposure to air pollution on lung function is higher in preterm than in term infants. Methods In the prospective BILD-birth-cohort of 254 preterm and 517 term infants, we investigated associations of particulate matter (PM10) and nitrogen dioxide with lung function at 44 weeks postconceptional age and exhaled markers of inflammation and oxidative stress response (fraction of exhaled nitric oxide (FeNO)) in an explorative hypothesis-driven study design. Multilevel mixed-effects models were used and adjusted for known confounders. Measurements and Main Results Significant associations of PM10 during the second trimester of pregnancy with lung function and FeNO were found in term and preterm infants. Importantly, we observed stronger positive associations in preterm infants (born 32 - 36 weeks), with an increase of [184.9 (79.1, 290.7) mL/min] minute ventilation per 10 µg/m3 increase in PM10 than in term infants [75.3 (19.7, 130.8) mL/min] (pprematurity × PM10 interaction = 0.04, after multiple comparison adjustment padj = 0.09). Associations of PM10 and FeNO differed between moderate to late preterm [3.4 (-0.1, 6.8) ppb] and term [-0.3 (-1.5, 0.9) ppb] infants, the interaction with prematurity was significant (pprematurity × PM10 interaction = 0.006, padj = 0.036). Conclusion Preterm infants showed significant higher susceptibility even to low-to-moderate prenatal air pollution exposure than term infants, leading to increased impairment of postnatal lung function. FeNO results further elucidate differences in inflammatory/oxidative stress response comparing preterms to terms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Decrue, Fabienne, Salem, Yasmin, Usemann, Jakob, Korten, Insa Christina Severine, Fuchs, Oliver, Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1535-4970

Publisher:

American Thoracic Society

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

27 Dec 2021 13:40

Last Modified:

22 Jun 2023 15:17

Publisher DOI:

10.1164/rccm.202102-0272OC

PubMed ID:

34587471

Uncontrolled Keywords:

COPD Longitudinal Studies Particulate Matter Premature Infants Prenatal Injuries

BORIS DOI:

10.48350/163045

URI:

https://boris.unibe.ch/id/eprint/163045

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