Bauer, Andreas; Korten, Insa; Juchem, Gerd; Kiesewetter, Isabel; Kilger, Erich; Heyn, Jens (2021). EuroScore and IL-6 predict the course in ICU after cardiac surgery. European journal of medical research, 26(1), p. 29. BioMed Central 10.1186/s40001-021-00501-1
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BACKGROUND
Despite modern advances in intensive care medicine and surgical techniques, mortality rates in cardiac surgical patients are still about 3%. Considerable efforts were made to predict morbidity and mortality after cardiac surgery. In this study, we analysed the predictive properties of EuroScore and IL-6 for mortality in ICU, prolonged postoperative mechanical ventilation, and prolonged stay in ICU.
METHODS
We enrolled 2972 patients undergoing cardiac surgery. The patients either underwent aortic valve surgery (AV), mitral valve surgery (MV), coronary artery bypass grafting (CABG), and combined operations of aortic valve and coronary artery bypass grafting (AV + CABG) or of mitral and tricuspid valve (MV + TV). Different laboratory and clinical parameters were analysed.
RESULTS
EuroScore as well as IL-6 were associated with increased mortality after cardiac surgery. Furthermore, a higher EuroScore and elevated levels of IL-6 were predictors for prolonged mechanical ventilation and a longer stay in ICU. Especially, highly significant elevated IL-6 levels and an increased EuroScore showed a strong association. Statistics suggested superiority when both parameters were combined in a single model.
CONCLUSION
Our results suggest that EuroScore and IL-6 are helpful in predicting the course in ICU after cardiac surgery, and therefore, the use of intensive care resources. Especially, the combination of highly elevated levels of IL-6 and EuroScore may prove to be excellent predictors for an unfortunate postoperative course in ICU.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie) 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology |
UniBE Contributor: |
Korten, Insa Christina Severine |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2047-783X |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
27 Dec 2021 13:52 |
Last Modified: |
05 Dec 2022 15:59 |
Publisher DOI: |
10.1186/s40001-021-00501-1 |
PubMed ID: |
33771227 |
Uncontrolled Keywords: |
Cardiac surgery EuroScore IL-6 Intensive care medicine Outcome |
BORIS DOI: |
10.48350/163046 |
URI: |
https://boris.unibe.ch/id/eprint/163046 |
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