The endocrine milieu in naturally matured follicles is different in women with high serum anti-Müllerian hormone concentrations.

von Wolff, Michael; Mitter, Vera Ruth; Jamir, Nadia; Stute, Petra; Eisenhut, Markus; Bersinger, Nick A. (2021). The endocrine milieu in naturally matured follicles is different in women with high serum anti-Müllerian hormone concentrations. Reproductive biomedicine online, 43(2), pp. 329-337. Elsevier 10.1016/j.rbmo.2021.01.021

Text 34176772_1-s2.0-S1472648321000523-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

RESEARCH QUESTION

Is the endocrine milieu different in women with low serum anti-Müllerian hormone (AMH) concentration compared with women with high concentration?

DESIGN

Cohort study of 84 women (four groups) classified according to AMH concentration and age undergoing natural cycle IVF treatment. Concentrations of LH, oestradiol, testosterone, androstenedione and AMH were determined in follicular fluid (FF), associations analysed and clinical outcome parameters evaluated.

RESULTS

A positive correlation between serum and FF AMH concentrations was confirmed. Follicular fluid androstenedione concentration was positively correlated with serum AMH concentration (P < 0.0001, r2 = 0.197). The correlation between FF LH and FF testosterone concentration in all women was not significant (P = 0.050, r2 = 0.046); however, the correlation between FF androstenedione in women with high serum AMH concentration was significant (P = 0.032, r2 = 0.220). Follicular fluid testosterone and androstenedione were positively correlated with FF oestradiol overall and in some individual groups. The high serum AMH concentration group showed the highest FF AMH and androstenedione concentrations and lowest oestradiol-testosterone and oestradiol-androstenedione ratios. High FF AMH concentration was associated with a higher clinical pregnancy rate and high FF oestradiol concentration with a slightly better embryo quality.

CONCLUSIONS

Differences in the endocrine milieu in women with high serum AMH concentration seem to be caused by increased follicular LH concentration. In women with high serum AMH concentration, FF androstenedione is increased and ratios of oestradiol-testosterone and oestradiol-androstenedione are decreased, suggesting a disturbed endocrine milieu caused by reduced metabolization of FF androgens into oestrogens. In natural cycles, FF AMH concentrations are positively associated with higher clinical pregnancy rates and oestradiol concentrations with a higher embryo score.

Interest & Impact

Downloads

2 since deposited on 27 Dec 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item