Park, Sang-Don; Orban, Mathias; Karam, Nicole; Lubos, Edith; Kalbacher, Daniel; Braun, Daniel; Stolz, Lukas; Neuss, Michael; Butter, Christian; Praz, Fabien; Kassar, Mohammad; Petrescu, Aniela; Pfister, Roman; Iliadis, Christos; Unterhuber, Matthias; Lurz, Philipp; Thiele, Holger; Baldus, Stephan; von Bardeleben, Stephan; Blankenberg, Stefan; ... (2021). Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. JACC. Cardiovascular Interventions, 14(8), pp. 819-827. Elsevier 10.1016/j.jcin.2020.12.042
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OBJECTIVES
The authors sought to assess sex-based differences in characteristics and outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for secondary mitral regurgitation (SMR).
BACKGROUND
Subgroup analysis from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial indicated potential sex-related differences in outcomes after TMVR. The impact of sex on results after TMVR in a real-world setting is unknown.
METHODS
The authors assessed clinical outcomes and echocardiographic parameters in women and men undergoing TMVR for SMR between 2008 and 2018 who were included in the large, international, multicenter real-world EuroSMR registry (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation).
RESULTS
A total of 1,233 patients, including 445 women (36%) and 788 men (64%), were analyzed. Although women were significantly older and had fewer comorbidities than men, TMVR was equally effective in women and men (mitral regurgitation [MR] grade ≤2+ at discharge: 93.2% vs. 94.6% for women vs. men; p = 0.35). All-cause mortality at 1 year (17.9% vs. 18.9%, adjusted hazard ratio: 0.806; p = 0.46) and at 2-year follow-up (26.5% vs. 26.4%, adjusted hazard ratio: 0.757; p = 0.26) were similar in women versus men after multivariate regression analysis. Durability of MR reduction, improvement in symptoms, quality of life, and functional capacity did also not differ during follow-up.
CONCLUSIONS
Results from the EuroSMR registry confirmed effective and similar MR reduction with TMVR in women and men. There were no sex-related differences in clinical outcomes up to 2 years of follow-up.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Praz, Fabien Daniel, Kassar, Mohammad, Windecker, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1876-7605 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Nadia Biscozzo |
Date Deposited: |
20 Jan 2022 14:36 |
Last Modified: |
05 Dec 2022 15:59 |
Publisher DOI: |
10.1016/j.jcin.2020.12.042 |
PubMed ID: |
33812815 |
Uncontrolled Keywords: |
MitraClip heart failure secondary mitral regurgitation sex transcatheter edge-to-edge mitral valve repair |
BORIS DOI: |
10.48350/163215 |
URI: |
https://boris.unibe.ch/id/eprint/163215 |
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