Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience.

Armario, Xavier; Rosseel, Liesbeth; Kharbanda, Rajesh; Khogali, Saib; Abdel-Wahab, Mohamed; Van Mieghem, Nicolas M; Tchétché, Didier; Dumonteil, Nicolas; De Backer, Ole; Cotton, James; McGrath, Brian; Balakrishnan, Deepu; Ali, Noman; Farhan, Serdar; Joseph, Jubin; Charbonnier, Gaetan; Okuno, Taishi; McHugh, Fiachra; Hildick-Smith, David; Gilgen, Nicole; ... (2021). Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience. JACC. Cardiovascular Interventions, 14(2), pp. 172-181. Elsevier 10.1016/j.jcin.2020.09.044

[img] Text
Transcatheter_Aortic_Valve_Replacement_with_the_LOTUS.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB)

OBJECTIVES

The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system.

BACKGROUND

The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device.

METHODS

A multicenter, single-arm, retrospective registry was initiated to evaluate short-term clinical outcomes. Included cases are the first experience with this device and new implantation technique in Europe. Clinical, echocardiographic, and computed tomographic data were analyzed. Endpoints were defined according to Valve Academic Research Consortium-2 and were site reported.

RESULTS

Between April and November 2019, 286 consecutive patients undergoing TAVR with the LOTUS Edge system at 18 European centers were included. The mean age and Society of Thoracic Surgeons score were 81.2 ± 6.9 years and 5.2 ± 5.4%, respectively. Nearly one-half of all patients (47.9%) were considered to have complex anatomy. Thirty-day major adverse events included death (2.4% [n = 7]) and stroke (3.5% [n = 10]). After TAVR, the mean aortic valve area was 1.9 ± 0.9 cm2, and the mean transvalvular gradient was 11.9 ± 5.7 mm Hg. None or trace paravalvular leak (PVL) occurred in 84.4% and moderate PVL in 2.0%. There were no cases of severe PVL. New permanent pacemaker (PPM) implantation was required in 25.9% among all patients and 30.8% among PPM-naive patients.

CONCLUSIONS

Early experience with the LOTUS Edge system demonstrated satisfactory short-term safety and efficacy, favorable hemodynamic data, and very low rates of PVL in an anatomically complex cohort. New PPM implantation remained high. Further study will evaluate if increasing operator experience with the device and new implantation technique can reduce the incidence of PPM implantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Okuno, Taishi, Pilgrim, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1876-7605

Publisher:

Elsevier

Language:

English

Submitter:

Nadia Biscozzo

Date Deposited:

21 Jan 2022 11:36

Last Modified:

05 Dec 2022 16:00

Publisher DOI:

10.1016/j.jcin.2020.09.044

PubMed ID:

33478633

Uncontrolled Keywords:

aortic valve stenosis transcatheter aortic valve replacement transcatheter heart valve

BORIS DOI:

10.48350/163309

URI:

https://boris.unibe.ch/id/eprint/163309

Actions (login required)

Edit item Edit item
Provide Feedback