Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component.

de Brot, Simone; Lothion-Roy, Jennifer; Grau-Roma, Llorenç; White, Emily; Guscetti, Franco; Rubin, Mark A.; Mongan, Nigel P (2022). Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component. Veterinary and comparative oncology, 20(1), pp. 38-49. Wiley 10.1111/vco.12704

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A limited number of species, including men and dogs, spontaneously develop prostate cancer (PC). The histological and molecular relevance of canine PC as a model for the disease in men remains controversial. To address this challenge, this study aimed to assess the histomorphology and expression of basal cell, urothelial and neuroendocrine markers [p63, high molecular weight cytokeratin (HMWCK), Uroplakin 3 (UPIII), neuron-specific enolase (NSE)] in canine PC (n = 41). Based on histomorphology, 10/41 (24%), 21/41 (51%) and 9/41 (22%) were classified as adenocarcinoma (AC), urothelial carcinoma (UC), and mixed carcinoma, respectively. Tumour inflammation was common, frequently severe [20/41 (49%)], and associated with neutering (p < .02) and urothelial differentiation (p < .02). Most (36/40, 90%) cancers contained only rare cells with basal cell marker expression or were negative. The expression of UPIII was absent or weak in the majority (33/38, 87%) of tumours, with moderate to strong staining in the remaining cases. NSE expression in PC was rare and limited to 2/14 (14%) cases. Tumour extension into benign ducts and glands was a common finding with presence in 17/39 (44%) of carcinomas with and without urothelial differentiation. In conclusion, we confirm that canine PC is characterized by absent or weak expression of basal cell and urothelial markers. Although rare, NSE expression, potentially indicating neuroendocrine differentiation, is reported for the first time in canine PCa. Intraductal carcinoma of the prostate with concurrent invasive PCa (IDCP-inv) is a frequent, not previously described, finding in dogs with PC.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

De Brot, Simone Danielle, Grau Roma, Llorenç, Rubin, Mark Andrew

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1476-5810

Publisher:

Wiley

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

24 Jan 2022 11:33

Last Modified:

05 Dec 2022 16:00

Publisher DOI:

10.1111/vco.12704

PubMed ID:

33963663

Uncontrolled Keywords:

canine histopathology immunohistochemistry p63 prostate carcinoma uroplakin

BORIS DOI:

10.48350/163457

URI:

https://boris.unibe.ch/id/eprint/163457

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