[Pentoxifylline and tocopherol - The importance in the treatment of osteoradionecrosis - Literature review and case report].

Marjanowski, Simon David; Maldonado, Alejandra; Schaller, Benoît; Burkhard, John-Patrik Matthias (2021). [Pentoxifylline and tocopherol - The importance in the treatment of osteoradionecrosis - Literature review and case report]. Swiss dental journal, 131(9), pp. 713-718. Schweizerische Zahnärzte-Gesellschaft SSO

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Osteoradionecrosis (ORN) is a serious complication after radiotherapy for head and neck cancer and is a challenging condition for both the therapist and the patient because of its difficult treatment. Different non-invasive approaches have been published for the treatment of low-grade ORN cases without establishing a standard regimen for treatment. Based on the approach of ORN pathogenesis, the so-called radiatio-induced fibroathrophic process (RIF), a new treatment concept with pentoxifylline and tocopherol (PENTO) has been published. The results of PENTO therapy seem promising as a conservative treatment approach for mild ORN or as an alternative when surgical intervention is not possible or desired. The present study summarizes the current state of the literature and shows the effectiveness of PENTO therapy based on a case report.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Marjanowski, Simon David, Schaller, Benoît, Burkhard, John Patrik Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2296-6498

Publisher:

Schweizerische Zahnärzte-Gesellschaft SSO

Language:

German

Submitter:

Caroline Dominique Zürcher

Date Deposited:

24 Jan 2022 15:51

Last Modified:

05 Dec 2022 16:00

PubMed ID:

34472712

Uncontrolled Keywords:

Osteoradionekrose Pentoxifyllin Radiotherapie Tocopherol

URI:

https://boris.unibe.ch/id/eprint/163491

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