Fujioka-Kobayashi, Masako; Andrejova, Elena; Katagiri, Hiroki; Schaller, Benoit; Sculean, Anton; Imber, Jean-Claude; Lang, Niklaus P.; Saulacic, Nikola (2021). Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect. Materials, 14(13) MDPI 10.3390/ma14133740
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The cross-linking of collagen matrices (Cl_CM) may provide volume-stable enhanced defect regeneration when compared to non-cross-linked matrices (Ncl_CM). The aim of the present study was to investigate the bone forming potential of collagen matrices (CMs) and the effects of cross-linking CMs in a rabbit calvaria defect model. (1) Empty controls (n = 6), (2) Ncl_CM (n = 8), and (3) Cl_CM (n = 8) were selected to be observed for the healing in 10 mm critical-sized calvarial bone defects. The potential for the bone as well as the connective tissue formation were evaluated by micro-CT and histomorphometry at three months post-surgery. There were no statistically significant differences in terms of new bone volume in the defects between the groups. However, the Cl_CM induced significantly greater fibrous tissue regeneration (5.29 ± 1.57 mm2) when compared to the controls (3.51 ± 0.93 mm2) by histomorphometry. The remnants of collagen fibers with immune cells, including macrophages and giant cells, were occasionally observed in the Cl_CM group but not in the Ncl_CM group. In conclusion, the cross-linking of collagen did not influence the potential for bone formation. Nevertheless, Cl_CM might be advantageous for the maintenance of fibrous tissue volume without disturbing bone formation in the defects.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery |
UniBE Contributor: |
Katagiri, Hiroki, Schaller, Benoît, Sculean, Anton, Imber, Jean-Claude, Lang, Niklaus Peter, Saulacic, Nikola |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1996-1944 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Caroline Dominique Zürcher |
Date Deposited: |
14 Jan 2022 13:20 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/ma14133740 |
PubMed ID: |
34279311 |
Uncontrolled Keywords: |
bone formation collagen cross-linking tissue augmentation |
BORIS DOI: |
10.48350/163494 |
URI: |
https://boris.unibe.ch/id/eprint/163494 |
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