Pre-clinical evaluation of the effect of a volume-stable collagen matrix on periodontal regeneration in two-wall intrabony defects.

Imber, Jean-Claude; Bosshardt, Dieter; Stähli, Alexandra; Saulacic, Nikola; Deschner, James; Sculean, Anton (2021). Pre-clinical evaluation of the effect of a volume-stable collagen matrix on periodontal regeneration in two-wall intrabony defects. Journal of clinical periodontology, 48(4), pp. 560-569. Wiley 10.1111/jcpe.13426

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AIM

To histologically evaluate the effect of a new collagen matrix on periodontal regeneration.

MATERIALS AND METHODS

Two-wall intrabony defects were surgically created bilaterally distally to the maxillary first and third pre-molars in beagle dogs. The defects were randomly allocated to open flap debridement either with (test) or without (control) a volume-stable collagen matrix (VCMX). After 12 weeks, the dogs were euthanized, and the specimens histologically processed. Descriptive, histomorphometrical (vertical gain of periodontal tissues) and statistical analyses were then performed.

RESULTS

Healing was uneventful in most cases. Residual VCMX was still present and showed integration into new bone, new periodontal ligament, connective tissue and, in some specimens, into new cementum. Periodontal regeneration occurred to a varying extent in both groups. New continuous cementum and new bone formation were statistically significantly greater in the test group (4.12 mm and 3.28 mm, respectively) than in the control group (1.54 mm and 2.47 mm, respectively) (p = .009 and p = .037, respectively). The junctional epithelium was longer in the control group (2.21 mm) than in the test group (1.49 mm, p = .16).

CONCLUSION

The present results have for the first time provided histologic evidence for the potential of this novel VCMX to facilitate periodontal regeneration thus warranting further pre-clinical and clinical testing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Imber, Jean-Claude; Bosshardt, Dieter; Stähli, Alexandra Beatrice; Saulacic, Nikola and Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1600-051X

Publisher:

Wiley

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

14 Jan 2022 13:28

Last Modified:

14 Jan 2022 13:34

Publisher DOI:

10.1111/jcpe.13426

PubMed ID:

33471389

Uncontrolled Keywords:

biomaterial histology intrabony defect periodontal regeneration volume-stable collagen matrix

BORIS DOI:

10.48350/163497

URI:

https://boris.unibe.ch/id/eprint/163497

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