Do Patients with a Family or Personal History of Venous Thromboembolism have an Increased Risk of Recurrence?

Florin, Jonas; Stalder, Odile; Baumgartner, Christine; Méan, Marie; Rodondi, Nicolas; Aujesky, Drahomir (2021). Do Patients with a Family or Personal History of Venous Thromboembolism have an Increased Risk of Recurrence? (In Press). Thrombosis and haemostasis Thieme 10.1055/s-0041-1740184

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BACKGROUND

A family (FH) and personal history (PH) of venous thromboembolism (VTE) are commonly evaluated risk factors for recurrence. We examined the association between FH/PH of VTE and the risk of recurrence and whether a stronger history status (i.e., both FH/PH vs. no FH/PH) carries an increased recurrence risk.

METHODS

We prospectively followed 813 patients aged ≥ 65 years with acute VTE from 9 Swiss hospitals. We classified patients into four groups: no FH/PH, FH only, PH only, and both FH/PH. The primary outcome was recurrent VTE during the full observation period. We examined the association between FH/PH status and the time to VTE recurrence using competing risk regression, adjusting for confounders and periods of anticoagulation.

RESULTS

Of 813 patients with VTE, 59% had no FH/PH, 11% a FH only, 24% a PH only, and 7% had both a FH and PH of VTE. Overall, 105 patients had recurrent VTE during the full observation period. After adjustment, patients with a FH only (subhazard ratio [SHR] 0.8, 95% confidence interval [CI] 0.4-1.7), PH only (SHR 1.5, 95% CI 0.9-2.5), and both FH/PH (SHR 1.4, 95% CI 0.6-3.1) did not have an increased risk of recurrent VTE compared with those without FH/PH. When we considered the period after the completion of initial anticoagulation only, the results were similar.

CONCLUSION

Our findings indicate that in patients with acute VTE, a FH and/or PH of VTE does not convey an increased risk of recurrent VTE. In particular, we did not find a "dose-effect" relationship between FH/PH status and VTE recurrence.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Florin, Jonas; Stalder, Odile; Baumgartner, Christine; Rodondi, Nicolas and Aujesky, Drahomir

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2567-689X

Publisher:

Thieme

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

04 Jan 2022 19:12

Last Modified:

29 Apr 2022 08:52

Publisher DOI:

10.1055/s-0041-1740184

PubMed ID:

34963186

BORIS DOI:

10.48350/163534

URI:

https://boris.unibe.ch/id/eprint/163534

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