Hernandez-Prera, Juan C; Skálová, Alena; Franchi, Alessandro; Rinaldo, Alessandra; Vander Poorten, Vincent; Zbären, Peter; Ferlito, Alfio; Wenig, Bruce M (2021). Pleomorphic adenoma: the great mimicker of malignancy. Histopathology, 79(3), pp. 279-290. Wiley 10.1111/his.14322
Full text not available from this repository. (Request a copy)Pleomorphic adenoma (PA) is the most common salivary gland neoplasm, and its diagnosis is straightforward in the majority of cases. However, not infrequently, PA shows unusual and uncommon histological features that can be confused with those of malignancy. The difficulties in diagnosing PA arise from its ability to mimic invasion, show atypical or metaplastic cytomorphology, and show morphological features that overlap with those of established salivary gland carcinomas. In addition, recognising early malignant transformation to carcinoma ex-pleomorphic adenoma continues to be a frequent challenge. This review describes the diagnostic pitfalls of PA, and offers a systematic approach to avoid them by combining classic histopathology with novel immunohistochemical and molecular tests.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) |
UniBE Contributor: |
Zbären, Peter |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1365-2559 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Stefan Weder |
Date Deposited: |
25 Jan 2022 11:08 |
Last Modified: |
05 Dec 2022 16:00 |
Publisher DOI: |
10.1111/his.14322 |
PubMed ID: |
33368685 |
Uncontrolled Keywords: |
MAML2 MYB PLAG1 early carcinoma ex pleomorphic adenoma invasion oncocytic metaplasia pleomorphic adenoma squamous metaplasia |
URI: |
https://boris.unibe.ch/id/eprint/163535 |
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