Frozen section in thyroid gland follicular neoplasms: It's high time to abandon it!

Sanabria, Alvaro; Zafereo, Mark; Thompson, Lester D R; Hernandez-Prera, Juan C; Kowalski, Luiz P; Nixon, Iain J; Shaha, Ashok; Rodrigo, Juan P; Mäkitie, Antti; Poorten, Vincent Vander; Suarez, Carlos; Zbären, Peter; Rinaldo, Alessandra; Ferlito, Alfio (2021). Frozen section in thyroid gland follicular neoplasms: It's high time to abandon it! Surgical oncology, 36, pp. 76-81. Elsevier 10.1016/j.suronc.2020.12.005

[img] Text
1-s2.0-S096074042030462X-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (4MB)

Thyroid nodules are a very common clinical condition. The 2015 American Thyroid Association (ATA) guidelines recommend surgical excision for Bethesda IV nodules. The use of intraoperative frozen section (FS) has been recommended as a strategy to tailor the extent of the initial surgery. We critically evaluated the literature that discusses the utility and cost-effectiveness of FS to make an intraoperative decision in patients with thyroid nodules classified as follicular neoplasm. FS should not be recommended as a routine intraoperative test to assess for malignancy in thyroid follicular patterned lesions due to its low performance; the high number of deferred results; the inability to adequately assess histologically defining features; the improvements in risk stratification guiding total thyroidectomy; and the low cost-effectiveness of FS.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Zbären, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0960-7404

Publisher:

Elsevier

Language:

English

Submitter:

Stefan Weder

Date Deposited:

25 Jan 2022 11:19

Last Modified:

05 Dec 2022 16:00

Publisher DOI:

10.1016/j.suronc.2020.12.005

PubMed ID:

33316682

Uncontrolled Keywords:

Carcinoma Follicular neoplasm Frozen section Thyroid nodule Thyroidectomy

BORIS DOI:

10.48350/163536

URI:

https://boris.unibe.ch/id/eprint/163536

Actions (login required)

Edit item Edit item
Provide Feedback