Huart, Caroline; Philpott, Carl M; Altundag, Aytug; Fjaeldstad, Alexander W; Frasnelli, Johannes; Gane, Simon; Hsieh, Julien W; Holbrook, Eric H; Konstantinidis, Iordanis; Landis, Basile N; Macchi, Alberto; Mueller, Christian A; Negoias, Simona; Pinto, Jayant M; Poletti, Sophia C; Ramakrishnan, Vijay R; Rombaux, Philippe; Vodicka, Jan; Welge-Lüessen, Antje; Whitcroft, Katherine L; ... (2021). Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view. International forum of allergy & rhinology, 11(7), pp. 1041-1046. Wiley 10.1002/alr.22788
Full text not available from this repository.The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) |
UniBE Contributor: |
Poletti, Sophia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2042-6984 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Stefan Weder |
Date Deposited: |
25 Jan 2022 11:41 |
Last Modified: |
05 Dec 2022 16:00 |
Publisher DOI: |
10.1002/alr.22788 |
PubMed ID: |
33728824 |
Uncontrolled Keywords: |
COVID-19 SARS-CoV-2 corticosteroids olfaction disorder smell |
URI: |
https://boris.unibe.ch/id/eprint/163547 |
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