Outcomes after reperfusion therapies in patients with ACA stroke: A multicenter cohort study from the EVATRISP collaboration.

Filioglo, A; Simaan, N; Honig, A; Heldner, M R; von Rennenberg, R; Pezzini, A; Padjen, V; Rentzos, A; Altersberger, V L; Baumgartner, P; Zini, A; Grisendi, I; Aladdin, S; Gomori, J M; Pilgram-Pastor, S M; Scheitz, J F; Magoni, M; Berisavac, I; Nordanstig, A; Psychogios, M; ... (2022). Outcomes after reperfusion therapies in patients with ACA stroke: A multicenter cohort study from the EVATRISP collaboration. Journal of the neurological sciences, 432, p. 120081. Elsevier 10.1016/j.jns.2021.120081

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Patients with stroke secondary to occlusions of the anterior cerebral artery (ACA) often have poor outcomes. The optimal acute therapeutic intervention for these patients remains unknown.


Patients with isolated ACA-stroke were identified from 10 centers participating in the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) prospective registry. Patients treated with endovascular thrombectomy (EVT) were compared to those treated with intravenous thrombolysis (IVT). Odds ratios with 95% confidence intervals (OR; 95%CI) were calculated using multivariate regression analysis.


Included were 92 patients with ACA-stroke. Of the 92 ACA patients, 55 (60%) were treated with IVT only and 37 (40%) with EVT (±bridging IVT). ACA patients treated with EVT had more often wake-up stroke (24% vs. 6%, p = 0.044) and proximal ACA occlusions (43% vs. 24%, p = 0.047) and tended to have higher stroke severity on admission [NIHSS: 10.0 vs 7.0, p = 0.054). However, odds for favorable outcome, mortality or symptomatic intracranial hemorrhage did not differ significantly between both groups. Exploration of the effect of clot location inside the ACA showed that in patients with A1 or A2/A3 ACA occlusions the chances of favorable outcome were not influenced by treatment allocation to IVT or EVT.


Treatment with either IVT or EVT could be safe with similar effect in patients with ACA-strokes and these effects may be independent of clot location within the occluded ACA.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Heldner, Mirjam Rachel, Pilgram-Pastor, Sara Magdalena, Arnold, Marcel


600 Technology > 610 Medicine & health








Chantal Kottler

Date Deposited:

25 Jan 2022 14:09

Last Modified:

05 Dec 2022 16:00

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Anterior cerebral artery Cerebrovascular disease Endovascular Stroke Thrombectomy





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