Baum, Joanna; Braicu, Elena Ioana; Hunsicker, Oliver; Vergote, Ignace; Concin, Nicole; Van Nieuwenhuysen, Els; Feldheiser, Aarne; Achimas-Cadariu, Patriciu; Darb-Esfahani, Silvia; Berger, Astrid; Fetica, Bogdan; Mahner, Sven; Papadia, Andrea; Wölber, Linn; Gasparri, Maria Luisa; Vanderstichele, Adriaan; Benedetti Panici, Pierluigi; Mueller, Michael D; Ruscito, Ilary; Woopen, Hannah; ... (2021). Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis. International journal of gynecological cancer, 31(5), pp. 713-720. BMJ Publishing Group Ltd 10.1136/ijgc-2020-002023
Full text not available from this repository. (Request a copy)INTRODUCTION
Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian cancer.
METHODS
Long-term survivors were defined as patients living longer than 8 years after first diagnosis and were recruited within seven high volume centers across Europe from November 1988 to November 2008. The control group included patients with high-grade serous ovarian cancer with less than 5 years' survival identified from the systematic 'Tumorbank ovarian cancer' database. A subanalysis of Charité patients only was performed separately for in-depth analysis of tumor dissemination. Propensity score matching with nearest-neighbor caliper width was used to match long-term survivors and the control group regarding age, FIGO stage, and residual tumor.
RESULTS
A total of 276 patients with high-grade serous ovarian cancer were included, divided into 131 long-term survivors and 145 control group patients. After propensity score matching and multivariable adjustment, platinum sensitivity (p=0.002) was an independent favorable prognostic factor whereas recurrence (p<0.001) and ascites (p=0.021) were independent detrimental predictors for long-term survival. Significantly more long-term survivors tested positive for mutation in the BRCA1 gene than the BRCA2 gene (p=0.016). Intraoperatively, these patients had less tumor involvement of the upper abdomen at initial surgery (p=0.024). Complexity of surgery and surgical techniques were similar in both cohorts.
CONCLUSION
Platinum sensitivity constitutes a favorable factor for long-term survival whereas tumor involvement of the upper abdomen, ascites, and recurrence have a negative impact. Based on clinical estimation, long-term survival is associated with combinations of clinical, surgical, and molecular factors.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Mueller, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1525-1438 |
Publisher: |
BMJ Publishing Group Ltd |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
25 Jan 2022 15:39 |
Last Modified: |
05 Dec 2022 16:00 |
Publisher DOI: |
10.1136/ijgc-2020-002023 |
PubMed ID: |
33563640 |
Uncontrolled Keywords: |
BRCA1 protein gynecologic surgical procedures intestines operative ovary surgical procedures |
URI: |
https://boris.unibe.ch/id/eprint/163596 |
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